Higher BMI may surprisingly protect against death in critical illness, challenging decades of weight-loss advice. Research reveals complex biological mechanisms where metabolic reserves, mental health, and fitness matter more than the scale.
NAD+ precursors like NR and NMN can boost cellular health and longevity without calorie restriction. These vitamin B3 derivatives elevate NAD+ levels by 40–90%, improving insulin sensitivity, cardiovascular function, and mitochondrial biogenesis. Human trials show doses of 250–1,000 mg daily are safe and effective for metabolic benefits, though muscle strength gains remain inconsistent. Regulatory status varies: NR has GRAS approval in the U.S., while NMN is classified as a drug. Practical us...
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